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Novel Developments in Cryo‐EM of Biological Molecules

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Free Download Novel Developments in Cryo‐EM of Biological Molecules: Resolution in Time and State Space
English | 2024 | ISBN: 9814968765 | 553 Pages | PDF (True) | 56 MB
Cryo-EM, as it is currently practiced in many laboratories, is limited to the visualization of molecules that are in thermal equilibrium at the time before freezing. A further limitation is that the existing software does not fully exploit the information that is contained in the images of large ensembles of molecules in thermal equilibrium. This book is a collection of recent articles by the author, reprinted with introductions, and they mainly describe two novel methods in cryo-EM, one computational and the other experimental that requires the use of a microfluidic device. Both methods have the capacity to shed light on the dynamic behavior of biomolecules. Combined, they greatly expand the range of applications of cryo-EM.


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